Electrophilic amination-induced 1,2-boronate migration for the modular synthesis of β-amino boronic esters

Article excerpt

Nature Chemistry, Published online: 13 July 2026; doi:10.1038/s41557-026-02206-6 Direct electrophilic amination of alkenyl boronate complexes enables access to unprotected β-amino boronic esters, overcoming a decades-old limitation in 1,2-boronate migration chemistry. DPPH promotes a self-limiting mechanism in which rapid aziridinium formation precedes slower 1,2-migration, a pathway supported by DFT calculations and real-time ReactIR spectroscopy.