Alzheimer's tipping point revealed as brain immune cells hit a key transition

Article excerpt

Researchers studying brain tissue from cognitively healthy older adults and centenarians have identified a critical biological turning point in Alzheimer's disease: a transition in brain immune cells that may determine whether the disease's pathology actually causes dementia. The international team from VIB, KU Leuven, the UK-DRI, and Muna Therapeutics found distinct cellular programs and immune-cell states linked to disease progression and resilience. Published in Nature Medicine, the work suggests this transition could be key to understanding why some people develop cognitive decline while others remain unaffected despite having Alzheimer's-related brain changes.