Molecular neighbours reshape protein dynamics

Article excerpt

Nature Chemistry, Published online: 25 June 2026; doi:10.1038/s41557-026-02194-7 As proteins are dynamic molecular machines, to fully understand their functions we need to understand how they move. Now, nuclear magnetic resonance spectroscopy and molecular dynamics simulations reveal how motions of the GB1 protein domain are altered by its environment, suggesting that modulating structural plasticity could control protein function.