Emerging evidence links tire pollution to Alzheimer's risk

Article excerpt

A chemical called 6PPD-quinone (6PPD-Q), which forms when shaved-off tire particles come into contact with ozone, might interfere with the inner workings of brain cells, leading to Alzheimer's disease. Zhang and Zhang's new paper in the journal Open Medicine, "6PPD‑Quinone Exposure and Alzheimer's Disease: Insights from Integrative Network Pharmacology, Transcriptomics, Machine Learning, and Molecular Docking," is the first to systematically explore this link using data-driven computational methods.