Divergent and precise alkaloid remodelling with a small suite of reactions

Article excerpt

Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02164-z A deconstructive alkaloid remodelling strategy comprising a concise set of robust transformations is introduced. Twenty-six altered frameworks are synthesized, requiring an average of ~1.8 steps per analogue. In cellulo evaluation across ten cancer cell lines indicates that an expanded amine bridge and a deconstructed tricyclic analogue exhibit micromolar and nanomolar level activities, respectively.