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Male puberty is understudied, but when it starts may predict long-term health risks

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Boys who hit puberty unusually early or late may face distinct long-term health risks, yet researchers know far less about these patterns in males than females. A significant gender gap in puberty research means most studies focus on girls' development and its health consequences, leaving boys' trajectories largely unmapped. Scientists argue this blind spot matters: puberty timing in males could predict risks for conditions ranging from cardiovascular disease to mental health issues in adulthood. Addressing the imbalance requires more longitudinal studies tracking boys from adolescence through middle age, a costly and time-consuming undertaking that funders have historically deprioritized.

Puberty is an inevitable part of human maturation, and it increasingly appears to hold a key to understanding individuals’ risk for developing poor health outcomes later in life. Research in girls has established a significant relationship between disease risk and the timing of puberty onset.

Early puberty has been connected to a higher risk for illnesses including endometriosis, type 2 diabetes, heart disease, breast cancer, depression, eating disorders, uterine fibroids, and osteoarthritis, as well as all-cause mortality. Many of these health outcomes exist on a sliding scale where the risk increases as the age of puberty onset decreases. On the other end of the spectrum, late puberty has been associated with celiac disease, asthma, and poor sleep, but it’s also protective against some conditions. Both early and late puberty, before 8 and after 13 years old, are associated with early menopause, which comes with its own health risks.

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