Mitochondria reveal new TDP-43 signaling route tied to ALS and dementia

Article excerpt

Researchers have discovered a previously unknown communication pathway between mitochondria and RNA granules that could explain how TDP-43 protein buildup triggers neurodegenerative diseases like ALS and frontotemporal dementia. The finding, published in Nature Communications, identifies a specific molecular route through which toxic protein accumulation damages neurons. Scientists hope understanding this pathway will open new avenues for treating these currently incurable conditions that progressively destroy motor neurons and cognitive function. The discovery represents a step toward deciphering the cellular mechanisms underlying these devastating diseases.