TNF-alpha blocks new neurons in hippocampus, reveals inflammation pathway

Article excerpt

A molecule linked to chronic inflammation disrupts the brain's ability to create new neurons, uncovering a pathway with therapeutic potential for neurodegenerative diseases and neurological conditions. The King's College London study, published in Nature Communications, offers insight into how long-term inflammation may contribute to cognitive decline in disorders such as Alzheimer's disease, aging, depression and the lingering neurological effects of viral infections.