Raman imaging applied to cardiac tissue of Fabry disease model reveals molecular map of lipids in tissue

Article excerpt

How are disease-relevant molecules distributed within tissue? What changes occur even before they become visible under the microscope? Questions such as these are crucial for early diagnosis and targeted treatment in many diseases. Researchers at the Leibniz-Institut für Analytische Wissenschaften, ISAS have, for the first time, succeeded in combining two complementary analytical methods to create a high-resolution molecular map of tissue. Their map makes different biomolecules simultaneously visible and reveals their spatial distribution.