Ketones to ketyls by radical relocation

Article excerpt

Nature Chemistry, Published online: 25 June 2026; doi:10.1038/s41557-026-02181-y Transforming aliphatic aldehydes to ketyl-type radicals has frequently been used for the construction of carbon, carbon bonds, but related reactions of ketones have not yet been reported. This has now been achieved using a radical translocation strategy from ketone-derived silyl cyanohydrins.